Read More About Cancer Research | Publications

Science 2022

Genome-wide analysis of somatic noncoding mutation patterns in cancer

Dietlein F*, Wang AB, Fagre C, Tang A, Besselink N, Cuppen E, Li C, Sunyaev SR, Neal JT, Van Allen EM*. * joint corresponding authors

Nature Cancer 2021

Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology.

Reardon B, Moore ND, Moore NS, Kofman E, AlDubayan SH, Cheung ATM, Conway J, …, Mouw KW, Park J, Vokes NI, Dietlein F, Van Allen EM.

Journal of Nuclear Medicine 2021

An 89Zr-labeled PSMA tracer for PET/CT imaging of prostate cancer patients.

Dietlein F, Kobe C, Munoz Vazquez S, Fischer T, Endepols H, Hohberg M, Reifegerst M, Neumaier B, Schomaecker K, Drzezga AE, Dietlein M.

Molecular Imaging and Biology 2021

[18F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer.

Dietlein F, Mueller P, Kobe C, Endepols H, Hohberg M, Zlatopolskiy BD, Krapf P, Heidenreich A, Neumaier B, Drzezga A, Dietlein M.

Nature Genetics 2020

Integrated molecular drivers coordinate biological and clinical states in melanoma

Conway JR, Dietlein F, Taylor-Weiner A, AlDubayan S, Vokes N, Keenan T, Reardon B, He MX, …, Schadendorf D, Liu D, Van Allen EM.

Journal of Nuclear Medicine 2020

Intraindividual Comparison of (18)F-PSMA-1007 with Renally Excreted PSMA Ligands for PSMA PET Imaging in Patients with Relapsed Prostate Cancer.

Dietlein F, Kobe C, Hohberg M, Zlatopolskiy BD, …, Neumaier B, Drzezga A, Dietlein M.

Journal of Nuclear Medicine 2020

An (18)F-Labeled PSMA Ligand for PET/CT of Prostate Cancer: First-in-Humans Observational Study and Clinical Experience with (18)F-JK-PSMA-7 During the First Year of Application.

Dietlein F, Hohberg M, Kobe C, …, Heidenreich A, Neumaier B, Drzezga A, Dietlein M.

Nature Genetics 2020

Identification of cancer driver genes based on nucleotide context.

Dietlein F*&, Weghorn D&, Taylor-Weiner A, Richters A, Reardon B, Liu D, Lander ES, Van Allen EM*, Sunyaev SR*. *joint corresponding authors, &joint first authors

Cell Reports 2017

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

Brägelmann J*, Dammert MA*, Dietlein F*, Heuckmann JM, Choidas A, Böhm S, Richters A, …, Heukamp LC, Büttner R, Rauh D, Klebl BM, Thomas RK, Sos ML. *joint first authors

Journal of Nuclear Medicine 2017

PSA-Stratified Performance of (18)F- and (68)Ga-PSMA PET in Patients with Biochemical Recurrence of Prostate Cancer.

Dietlein F*, Kobe C, Neubauer S, Schmidt M, Stockter S, Fischer T, Schomäcker K, Heidenreich A, Zlatopolskiy BD, Neumaier B, Drzezga A, Dietlein M. *corresponding author

Cell 2015

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Dietlein F*, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, …, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC*. * joint corresponding authors

Clinical Cancer Research 2014 (Review)

Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy.

Dietlein F, Reinhardt HC.

Trends in Genetics 2014 (Review)

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches.

Dietlein F, Thelen L, Reinhardt HC.

Cancer Discovery 2014

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Dietlein F*, Thelen L*, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC. *joint first authors

Human Molecular Genetics 2014

Inferring primary tumor sites from mutation spectra: a meta-analysis of histology-specific aberrations in cancer-derived cell lines.

Dietlein F*, Eschner W. *corresponding author

Cancer Discovery 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Malchers F*, Dietlein F*, Schöttle J, Lu X, Nogova L, Albus K, Fernandez-Cuesta L, …, Reinhardt HC, Ringeisen F, Büttner R, Heukamp LC, Wolf J, Thomas RK. *joint first authors

PNAS 2012

A framework for identification of actionable cancer genome dependencies in small cell lung cancer.

Sos ML*, Dietlein F*, Peifer M, Schöttle J, Balke-Want H, Müller C, Koker M, Richters A, Heynck S, Malchers F, …, Waldmann H, Büttner R, Rauh D, Heukamp LC, Thomas RK. *joint first authors

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Dietlein Lab

Selected Publications